FLAMAZINE CREAM 500G (SILVER SULFADIAZINE 1%) PM
Unit Of Sale: EACH
Manufacturers Code: 66800532
Medent Code: 34920
Brand: S&N
The mechanism of silver sulfadiazine's antibacterial action has not been fully elucidated. After exposure to the drug, structural changes in the bacterial cell membrane occur, including distortion and enlargement of the cell and a weakening of the cell wall membrane. This is accompanied by reduced viability in sensitive strains due to interference with macromolecular synthesis. The sulfadiazine moiety also provides a bacteriostatic action against sensitive organisms.
In adults, up to 10% of the sulfadiazine may be absorbed and 60-85 % of the absorbed amount is excreted in the urine. In children with 13 % body surface area burns, the urinary sulfadiazine concentration was 31.8 mg/L.
|